My lab studies fundamental biological and biochemical pathways in human pathogens to identify ways to exploit their pathways as targets for rational drug design with limited capacity to evolve resistance.
We currently study: 1) malaria mitochondrial gene regulation, 2) molecular mechanisms of antimalarial drug resistance, and 3) genetic switches in bacteriophage residing in multi-drug resistant Staphylococcus aureus (MRSA) bacteria. Our malaria mitochondrion studies will identify new, highly conserved targets for drug development and the ways the parasite might develop resistance to those candidate drugs. Translational and applied bacteriophage genetics provide an opportunity to treat MRSA infections without the possibility of antibiotic resistance.